The objectives of the current study are to understand the effect of disability acceptance of workers with physical disabilities on their job satisfaction, as well as to identify the mediating effect of self-esteem and the moderating effect of employment type on the relationship between the level of disability acceptance and job satisfaction. To achieve this end answers provided by workers with physical disabilities in the second survey of the second wave of the Disability Employment Panel Survey (2017). Among the 4,577 samples in the survey, answers given by 4.214 subjects (excluding 363 non-responders) were used as the population, from which 935 workers with disabilities were selected. The following findings were made about the mediating effect of self-esteem and the moderating effect of employment type regarding the impact of disability acceptance of workers with physical disabilities on their job satisfaction: First, the level of disability acceptance was found to have a significant impact on job satisfaction. Sub-variables of job satisfaction such as work satisfaction factors (work content, communication, and interpersonal relationships, working environment, working hours, personal development potential) and policy satisfaction factors (employee welfare, wage or income, consideration and convenience for workers with disabilities, safety, fairness) were found to have significant effects as well. This indicates that workers with physical disabilities tend to have positive job satisfaction levels if they are not unhappy with their disabilities, accept their situation in a positive manner, and work with satisfaction about their lifestyle. The results also imply that the work satisfaction factors such as work content or working environment have more impact on job satisfaction than policy satisfaction factors such as employee welfare and wage. Second, the level of disability acceptance was found to have a positive effect on self-esteem. This can be interpreted as meaning that workers with physical disabilities can increase their self-esteem by accepting their disabilities without suffering and expanding their interpersonal relationships. Third, the self-esteem of workers with disabilities was found to have a significant impact on their job satisfaction. It was also found to have significant effects on sub-variables of job satisfaction such as work satisfaction factors and policy satisfaction factors. This may mean that higher self-esteem of workers with physical disabilities leads to higher job satisfaction for them. fourth, self-esteem was found to have a significant mediating effect on the relationship between the disability acceptance of workers with physical disabilities and their job satisfaction. It also had a significant mediating effect on work satisfaction factors and policy satisfaction factors, which are sub-variables of job satisfaction. This indicates that the self-esteem of workers with physical disabilities has a mediating effect on the impact of disability acceptance on job satisfaction. Fifth, the moderating effect of employment type in the relationship between disability acceptance and job satisfaction was found to be significant and negative. While there was no moderating effect on work satisfaction factors, sub-variables of job satisfaction, but there was a significant moderating effect on policy satisfaction factors. It is meaningful to confirm that the employment type has a significant negative moderating effect on the relationship between disability acceptance and job satisfaction.